Justin Benesch
Professor of Biophysical Chemistry
Contact
justin.benesch@chem.ox.ac.uk
01865 285420
Research group
My research focuses on developing and using new experimental methodologies that enable unprecedented quantitative insight into the states and structures that proteins adopt. In our group, we integrate the data we gather using these new techniques with computational strategies, incorporating evolutionary history and measurements of cellular activity to uncover the physico-chemical determinants of biomolecular function.
To overcome the structural heterogeneity frequently displayed by proteins and their complexes, we exploit the separative capabilities of mass spectrometry to probe and manipulate individual states—both at, and away from, equilibrium. This has allowed us to gain valuable insights into the processes of molecular recognition, and the regulation of protein interactions.