We work with synthetic biomolecular nanostructures built by self-assembly. Nucleic acid nanostructures are atomically precise and dynamically reconfigurable: by designing synthetic strands of DNA or RNA we can create autonomous molecular systems that sense, compute and actuate. We are developing the physics and technology of functional nucleic acid nanostructures to create disruptive technologies, including templates for molecular electronics and molecular machinery for atomically precise manufacture and chemical discovery. We are also working on probes of cellular structure and function.