George Tofaris
Professor of Neurology and Translational Neuroscience
Contact
george.tofaris@ndcn.ox.ac.uk
01865 234304
Research group
Molecular Neurodegeneration Research Group
My research aim is to delineate cellular pathways in protein quality control that could inform the development of novel biomarkers and targeted therapies in neurodegenerative and neurogenetic disorders. To this end, my group uses forward genetics, proteomics and transcriptomics in models of increasing cellular complexity, including patient-derived induced pluripotent stem cells (iPSC).
Of particular interest to my group is the cellular trafficking and aggregation of α-synuclein, a key protein in Parkinson's disease. We found that α-synuclein is ubiquitinated in human brain and discovered that this modification regulates the localisation of α-synuclein to endosomes for degradation by lysosomes. We have developed iPSC-based models to identify modifiers of its turnover and aggregation.
We are also interested in the role of mitochondrial dysfunction in hereditary forms of neurodegeneration and the study of circulating exosomes as biomarkers for Parkinson's disease prediction or stratification.